In a placebo controlled study of 96 elderly people over 70 years of age, supplementation with acetyl l-carnitine (ALC) was found to significantly reduce physical and mental fatigue and improve cognitive and physical function. Subjects were given ALC (2000 mg twice a day) or a placebo for 180 days. The ALC group experienced reductions in physical and mental fatigue and had improved functional status and cognitive functions. The results of this study suggest that supplementation with ALC may help to reduce fatigue in the elderly. Based on other research, this is not surprising, and especially if taken along with Ribose and CoEnzyme Q10, would also improve heart function in this population. I would only take 1000-1500 mg a day and not the higher dose used in this study.
"Acetyl-L-Carnitine (ALC) treatment in Elderly Patients with Fatigue," Malaguarnera M, Gargante MP, et al, Arch Gerontol Geriatr, 2007 Jul 19;
Jacob Teitelbaum, M.D. is one of the world's leading integrative medical authorities on fibromyalgia and chronic fatigue. He is the lead author of eight research studies on their effective treatments, and has published numerous health & wellness books, including the bestseller on fibromyalgia From Fatigued to Fantastic! and The Fatigue and Fibromyalgia Solution. Dr. Teitelbaum is one of the most frequently quoted fibromyalgia experts in the world and appears often as a guest on news and talk shows nationwide including Good Morning America, The Dr. Oz Show, Oprah & Friends, CNN, and Fox News Health.